Neuroendocrine Tumors Research Updates

In a retrospective cohort of 1,205 pediatric patients with de novo AML from the TARGET database, the authors compared MRD thresholds of ≥0.1% versus ≥0.05% after induction courses 1 and 2. ROC analysis identified 0.05% as the optimal threshold (AUC 0.840 after course 1 and 0.854 after course 2) and the 0.05% cutoff yielded higher hazard ratios for first event and significant net reclassification improvement versus 0.1%, supporting evaluation of the lower threshold in future trials while noting the study's retrospective, historical-data limitations.

In a chart review of 65 women with Lynch syndrome (age >30, intact uterus/ovaries, no prior uterine/ovarian cancer) at a safety-net hospital and a university medical center, uptake of risk-reducing gynecologic surgery was higher at the safety-net hospital (67.9% vs 35.1%) and occurred sooner. After controlling for age and prior non-gynecologic cancer, being treated at the safety-net hospital remained associated with greater likelihood of surgery (HR 2.43, p = 0.02); age, parity, Lynch gene, benign gynecologic diagnosis, family history, race/ethnicity, and language preference were not significantly associated with surgery uptake.

Eight federally qualified health centers implemented multicomponent evidence‑based interventions (eg, reminders, provider feedback, navigation) to increase fecal immunochemical test (FIT) colorectal cancer screening and reported an average uptake increase of 14.4 percentage points at an average intervention cost of $14.40 per person. From a public payer perspective, five centers' interventions produced net cost savings and the other three had cost‑effectiveness ratios of $14,898–$54,111 per life‑year saved, supporting these multicomponent strategies as effective and economically favorable for settings with low screening uptake.