Differential Effects of Degenerative Spine Disease and Spinal Fusion on the Risk and Progression of Hip Osteoarthritis: A Nationwide Time-Varying Cohort Study.
Hong, Seok Ha SH; An, Min Soo MS; Kong, Seok Jin SJ; et al.
In a nationwide time-varying cohort of 1,620,585 individuals aged ≥50 (2010–2022), degenerative spine disease (SPINE_DX) and spinal fusion (SPINE_FUSION) were modeled as exposures and compared with controls for incident hip osteoarthritis (HOA) and progression to total hip arthroplasty (THA). Both SPINE_DX (HR 1.66, 95% CI 1.64–1.68) and SPINE_FUSION (HR 1.22, 95% CI 1.19–1.25) were associated with increased HOA incidence, and among those with HOA progression to THA was higher with SPINE_FUSION (HR 2.32, 95% CI 2.06–2.62) and SPINE_DX (HR 1.51, 95% CI 1.41–1.62); results were consistent after inverse probability weighting.